NeuroVol Revolution™

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NeuroVol Revolution™

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PUMP AND FOCUS ENHANCER

Lifters have a certain appreciation for the enhancing effects of pre-workout supplements, but in some situations, you just need the focus and pump – none of the zip. Obviously, if you train after work, you don’t want your pre-workout to deprive you of all that anabolic sleep! NeuroVol is a stimulant-free, effectively-dosed pre-workout designed to help you crush the iron without any jittery aftershocks.

  • Nitrosigine – The world’s most effective form of arginine works synergistically with citrulline to maintain improved blood flow up to 3 hours.
  • Agmatine Sulfate – Induces vasodilation allowing more blood to reach working muscles.
  • Citrulline Malate – A dual-threat: Provides huge boosts to training volume and stimulates nitric oxide production. More training volume. Bigger pumps. Maximized gains.
  • Norvaline – Inhibits the breakdown of Nitric Oxide to keep more of it active in the system.
  • Choline Complex – Choline Bitartrate and CDP choline create acetylcholine, a neurotransmitter required for muscle contraction and focus.
(*To view complete supplement facts click on the ingredient profile tab below)

What makes NeuroVol special is that, along with the nitric oxide-induced, muscle-engorging pumps, we have included a Focal Matrix to help you attain great focus without any stimulatory ingredients. Don’t go without the best training sessions possible because your situation isn’t accommodating to stimulants, train with NeuroVol, and keep tearing up the gym.

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NEUROVOL-SUP-FACTS

Nitrosigine™ (Inositol Stabilized Arginine Silicate):

Arginine (NITROSIGINE) is a precursor to nitric oxide and expands blood vessels to optimize blood flow. Silicate is contained within the walls of the arteries to help maintain their structural integrity.

  • These ingredients works in synergy to help increase the blood flow and the structural integrity of the artery walls.
  • Preclinical data has shown that Nitrosigine is superior to standard arginine… with 2x the blood flow in vasodilatation response.

 

NX5 VASODILATION MATRIX

 

Agmatine Sulfate:

Agmatine Sulfate helps improve nutrient partitioning which leads to an increase in muscle glycogen (carbs stored in muscle tissues) which then leads to more water retained WITHIN the muscle. This creates a fuller look to the muscles and a greater pump while hitting the iron.

  • Agmatine Sulfate also increases NO production by working as a competitive inhibitor of the enzyme NO Synthase.
  • There are studies to suggest that the nutrient partitioning effects of agmatine sulfate are possibly due to its ability to increase the insulin response to carbohydrates. This could be further explained by the increased blood flow to the muscle that occurs with increased NO production.
  • LH and GH levels have been shown to be increased through the effects of Agmatine Sulfate and its possible effects on the hypothalamus.
  • Agmatine has also been shown to manipulate pain receptors which may allow you to train past normal pain thresholds.

Arginine Complex (Arginine Alpha-Ketoglutarate, Arginine HCL, Arginine Orotate, Arginine Ethyl Ester):

Arginine is a semi-essential amino acid and is a chemical precursor to nitric oxide (a blood vessel-widening agent).

  • When arginine enters the body it stimulates nitric oxide pathways. This process vasodilates (enlarges) blood vessels and helps deliver more of the much needed oxygen rich blood and nutrients to working muscles in order to achieve the pump and ultimately muscle growth.
  • Arginine also triggers the body to make protein and has been studied for healing wounds, bodybuilding, and preventing tissue degradation in people with critical illnesses.
  • A 2010 study conducted by Bailey et al. discovered supplemental arginine for 3 days was able to enhance nitric oxide production and decrease oxygen consumption (7%) while improving time to exhaustion by 25% in otherwise healthy men.

GlycoCarn™ (Glycine Propionyl-L-Carnitine HCL):

Glycocarn is a highly bioavailable form of Carnitine. Carnitine is crucial in muscle function by regulating energy flow across the cell membranes during strenuous activity.

  • Glycocarn can help increase nitric oxide levels. Increasing Nitric Oxide helps blood flow to organs and muscles and optimizes oxygen and nutrient delivery to the muscles.
  • All this can help to increase aerobic power, stamina, endurance, and recovery.
  • Jacobs et al. (2009) discovered that resistance trained males who supplemented with Glycocarn 90 minutes before exercise were able to increase peak power production (2-15%) and decrease lactic acid accumulation (15-17%).

Citrulline Malate:

Citrulline Malate is a non-essential amino acid that eventually converts to nitric oxide. Nitric oxide is a vasodilator that can help to lower blood pressure and improve blood flow to both organs and muscles.

  • Studies have shown that Citrulline Malate enhances exercise tolerance by reducing levels of blood ammonia and lactate that are typically elevated during strenuous exercise.
  • This ingredient will allow you to train with less rest in between sets and elevate your endurance capacity.
  • A recent research study found individuals who consumed citrulline malate for 15 days were able to increase ATP production during exercise by 34% and improve phospho-creatine resynthesis after exercise by 20%.

Taurine:

Taurine, has a myriad of benefits. From helping the body to metabolize fat, improving insulin sensitivity, raising testosterone levels, as an antioxidant, higher performance and quicker recovery during athletic training and increasing cardiovascular health… it goes without saying that Taurine is a great ingredient to have in your wheelhouse

  • Zhang et al. (2004) found that individuals who supplemented with taurine for 1 week before an exhaustive exercise bout significantly improved time to exhaustion, VO2 max, and maximal workload. It also decreased exercise induced DNA damage.

Glycerol:

Glycerol (1,2,3-propanetriol) is a colorless, odorless, sweet tasting sugar alcohol. When consumed glycerol is rapidly absorbed primarily in the small intestine, distributed equally among all fluid compartments, and promotes hyperhydration by inducing an osmotic gradient.

  • This brings potential benefits for endurance and stamina events, including adaptation to environmental heat/humidity stress, along with promoting blood flow associated with resistance training.
  • Glycerol has also been shown to help athletes store extra water, delaying the need for hydration. This suggests improved efficiency in exercise, thermoregulation and decreased physiological stress.
  • In addition, glycerol enhances plasma and intramuscular volume expansion, producing a more engorged muscular appearance.

Ornithine HCL:

Ornithine when bound by salt at the molecular level is much more bio-available than its free form.

  • Ornithine works in synergy with arginine in the metabolism of waste caused by intense exercise.
  • By increasing the nitric oxide production and decreasing waste you are able to train longer and decrease fatigue.
  • A 2008 study conducted by Sugino et al. discovered supplementation with ornithine was able to reduce perceptions of fatigue to 52% of placebo on a prolonged endurance test and was able to reduce ammonia accrual during exercise.

Norvaline:

L-Norvaline is an analog of the branched chain amino acid, valine. It can be found in foods such as dairy, meat, grains, soy and peanuts. Since valine is an essential amino acid, L-Norvaline has to be obtained through the diet or supplementation, as the body cannot produce it.

  • Norvaline works in conjunction with arginine and other nitric oxide precursors by extending or prolonging their activity.
  • By prolonging this period more nitric oxide production can occur, even when the muscle cells supply of arginine starts to run low.
  • One study has shown L-Norvaline can effectively increase the production of NO by as much as 60%.

Sodium BiCarbonate:

Sodium Bicarbonate is an extremely alkaline (low acidity/high pH), acid buffering agent that has been shown effective at increasing intra- and extracellular pH.

  • The main benefits of sodium bicarbonate supplementation is it can delay the onset of muscle fatigue and improve recovery from events requiring high-intensity bursts of anaerobic contractions of large muscle groups.
  • McNaughton et al. (1999) discovered 10 healthy male adult cyclists given sodium bicarbonate prior to exercise noted increased average power output in their 60 minute cycling test (13.7%)

Vanadyl Sulfate:

Vanadyl sulfate has been shown to significantly improve glycemic control and there-by improve liver and muscle sensitivity to insulin.

  • Studies suggest that vanadyl sulfate helps muscle cells uptake glucose, and may help you perform better and recover faster.
  • Halberstam et al. (1996) found that subjects taking small doses of vanadyl sulfate improved both hepatic and skeletal muscle insulin sensitivity by enhancing insulin’s inhibitory effect on lipolysis.

 

NEUROPURE™ FOCAL MATRIX

 

Choline Complex (Choline Bitartrate, CDP Choline):

Choline is an essential nutrient for brain health and synaptic plasticity.

  • Choline improves structural integrity, signaling capacity and the fluidity of neural membranes. It’s estimated that close to 90% of the population does not get the recommended amount of choline daily.
  • It has been shown that a dose of 500mg of Choline can boost focus, mood and concentration abilities.
  • This is tantamount to pushing through your workout. Utilizing this effectively dosed compound, you will be able to focus on taking less rest or being distracted during you training. Giving your 110% will really be your 110%.
  • A study conducted by Sun et al. (1999) reported that subjects who supplemented with choline for 4 weeks improved learning performance and memory compared to a placebo group.

 

 

 

Q: What is the best way to take NeuroVol Revolution?
A: Mix 1 scoop of NeuroVol™ with 8-10 fluid oz. of cold water and consume prior to training. For optimal results, combine NeuroVol™ with Rhino 2.0 (a stimulant based pre-workout).

Q: What exactly is “the pump” and does it do anything besides making your muscles look bigger?
A: From a scientific perspective the “pump”, commonly referred to as hyperemia, supplies working muscles with oxygen rich blood and nutrients while also removing waste products such as carbon dioxide. The more oxygenated blood and nutrients the muscles get the longer sustained contractions can take place…which ultimately leads to a pump and greater muscular growth. In fact, the cellular swelling that occurs with the pump may increase protein synthesis while also decreasing protein breakdown within the cell. This creates an optimal environment for muscle growth.

Q: What other MuscleSport products do you recommend stacking NeuroVol Revolution?
A: We recommend stacking NeuroVol Revolution with any of our pre-workout products to promote optimal performance, focus, and pump.

Nitrosigine™ (Inositol Stabilized Arginine Silicate):
1. Kalman, D. S., Feldman, S., Samson, A., & Krieger, D. R. (2015). A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clinical pharmacology: advances and applications, 7, 103.

Agmatine Sulfate:
1. Ahn, S. K., S. Hong, et al. (2011). “Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.” Brain Res 1373: 48-54.
2. Arndt, M. A., V. Battaglia, et al. (2009). “The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis.” Am J Physiol Cell Physiol 296(6): C1411-1419.
3. Berkels, R., D. Taubert, et al. (2004). “Agmatine signaling: odds and threads.” Cardiovasc Drug Rev 22(1): 7-16.
4. Gao, Y., B. Gumusel, et al. (1995). “Agmatine: a novel endogenous vasodilator substance.” Life Sci 57(8): PL83-86.
5. Haenisch, B., I. von Kugelgen, et al. (2008). “Regulatory mechanisms underlying agmatine homeostasis in humans.” Am J Physiol Gastrointest Liver Physiol 295(5): G1104-1110.
6. Halaris, A. and J. Plietz (2007). “Agmatine: metabolic pathway and spectrum of activity in brain.” CNS Drugs 21(11): 885-900.
7. L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide.
8. Keynan, O., Mirovsky, Y., Dekel, S., Gilad, V. H., & Gilad, G. M. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc‐associated Radiculopathy. An Open‐label, Dose‐escalating Study Followed by a Randomized, Double‐blind, Placebo‐controlled Trial. Pain Medicine, 11(3), 356-368.

Arginine Complex (Arginine Alpha-Ketoglutarate, Arginine HCL, Arginine Orotate, Arginine Ethyl Ester):
1. Tan, B., Yin, Y., Liu, Z., Li, X., Xu, H., Kong, X., … & Wu, G. (2009). Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino acids, 37(1), 169-175.
2. Huk, I., Nanobashvili, J., Neumayer, C., Punz, A., Mueller, M., Afkhampour, K., … & Patton, S. (1997). L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation, 96(2), 667-675.
3. Yao, K., Yin, Y. L., Chu, W., Liu, Z., Deng, D., Li, T., … & Wu, G. (2008). Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. The Journal of nutrition, 138(5), 867-872.
4. Jobgen, W., Meininger, C. J., Jobgen, S. C., Li, P., Lee, M. J., Smith, S. B., … & Wu, G. (2008). Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. The Journal of nutrition, jn-108.
5. Tseh, Wayland1; Cioci, Brian W.1; Morgan, Don W. FACSM2 The Effects of Arginine Alpha-Ketoglutarate Supplementation on Endurance-Trained Females http://journals.lww.com/acsm-msse/Citation/2008/05001/The_Effects_of_Arginine_Alpha_Ketoglutarate.2375.aspx
6. Thomas S. Rector, PhD; Alan J. Bank, MD; Kathleen A. Mullen, RN; Linda K. Tschumperlin, RN; Ronald Sih, MD; Kamalesh Pillai, MD; Spencer H. Kubo, MD Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients with Heart Failure http://circ.ahajournals.org/content/93/12/2135.full
7. E Morikawa, M A Moskowitz, Z Huang, T Yoshida, K Irikura and T Dalkara L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. http://stroke.ahajournals.org/content/25/2/429.short
8. S M Gardiner, A M Compton, T Bennett, R M Palmer, S Moncada Control of regional blood flow by endothelium-derived nitric oxide.

GlycoCarn™ (Glycine Propionyl-L-Carnitine HCL):
1. Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance. Jacobs PL, Goldstein ER. J Int Soc Sports Nutr. 2010 Oct 28;7:35. doi: 10.1186/1550-2783-7-35.
2. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Bloomer RJ, Tschume LC, Smith WA. Int J Vitam Nutr Res. 2009 May;79(3):131-41. doi: 10.1024/0300-9831.79.3.131.

Citrulline Malate:
1. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine,36(4), 282-289.
2. Hickner, R. C., Tanner, C. J., Evans, C. A., Clark, P. D., Haddock, A., Fortune, C., … & Mccammon, M. (2006). L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Medicine and science in sports and exercise, 38(4), 660-666.
3. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
4. Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-citrulline-malate influence over branched chain amino acid utilization during exercise. European journal of applied physiology, 110(2), 341-351.

Taurine:
1. Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., Yamagami, T., Liu, Z., & Qi, B. (2004). Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino acids, 26(2), 203-207.
2. BOUCHAMA, A., YUSUF, A., AL-SEDAIRY, S. U. L. T. A. N., & EL-YAZIGI, A. D. N. A. N. (1993). Alteration of taurine homeostasis in acute heatstroke.Critical care medicine, 21(4), 551-554.
3. Gwacham, N., & Wagner, D. R. (2012). Acute effects of a caffeine-taurine energy drink on repeated sprint performance of American college football players. Int J Sport Nutr Exerc Metab, 22(2), 109-116.
4. Warskulat, U., Brookmann, S., Felsner, I., Brenden, H., Grether‐Beck, S., & Häussinger, D. (2008). Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts. Experimental dermatology, 17(12), 1031-1036.

Glycerol:
1. Bartos, J. (2013). A uniquely optimized, highly concentrated powdered form of glycerol delivering next-level hydration and next-gen product potential http://astromicnutrition.com/HydroMax_WhitePaper.pdf
2. Riedesel, M. L., Allen, D. Y., Peake, G. T., & Al-Qattan, K. (1987). Hyperhydration with glycerol solutions. Journal of Applied Physiology, 63(6), 2262-2268.
3. Lyons, T. P., Riedesel, M. L., Meuli, L. E., & Chick, T. W. (1990). Effects of glycerol-induced hyperhydration prior to exercise in the heat on sweating and core temperature. Medicine and Science in Sports and Exercise, 22(4), 477-483.
4. Goulet, E. D., Robergs, R. A., Labrecque, S., Royer, D., & Dionne, I. J. (2006). Effect of glycerol-induced hyperhydration on thermoregulatory and cardiovascular functions and endurance performance during prolonged cycling in a 25 C environment. Applied Physiology, Nutrition, and Metabolism, 31(2), 101-109.
5. Montner, P., Stark, D. M., Riedesel, M. L., Murata, G., Robergs, R., Timms, M., & Chick, T. W. (1996). Pre-exercise glycerol hydration improves cycling endurance time. International journal of sports medicine, 17(1), 27-33.

Ornithine HCL:
1. Sugino, T., Shirai, T., Kajimoto, Y., & Kajimoto, O. (2008). L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutrition research, 28(11), 738-743.

Norvaline:
1. Chang, C. I., Liao, J. C., & Kuo, L. (1998). Arginase modulates nitric oxide production in activated macrophages. American Journal of Physiology-Heart and Circulatory Physiology, 274(1), H342-H348.

Sodium BiCarbonate:
1. Driller, M. W., Gregory, J. R., Williams, A. D., & Fell, J. W. (2012). The effects of serial and acute NaHCO3 loading in well-trained cyclists. The Journal of Strength & Conditioning Research, 26(10), 2791-2797.
2. McNaughton, L., Dalton, B., & Palmer, G. (1999). Sodium bicarbonate can be used as an ergogenic aid in high-intensity, competitive cycle ergometry of 1 h duration. European journal of applied physiology and occupational physiology, 80(1), 64-69.
3. Douroudos, I. I., Fatouros, I. G., Gourgoulis, V., Jamurtas, A. Z., Tsitsios, T., Hatzinikolaou, A., … & Taxildaris, K. (2006). Dose-related effects of prolonged NaHCO3 ingestion during high-intensity exercise. Medicine and science in sports and exercise, 38(10), 1746-1753.
4. Kilding, A. E., Overton, C., & Gleave, J. (2012). Effects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance. International Journal of Sport Nutrition andExercise Metabolism, 22(3), 175.

Vanadyl Sulfate:
1. Halberstam, M., Cohen, N., Shlimovich, P., Rossetti, L., & Shamoon, H. (1996). Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes, 45(5), 659-666.
2. Effect of acute and short-term administration of vanadyl sulphate on insulin sensitivity in healthy active humans.

Choline Complex (Choline Bitartrate, CDP Choline):
1. Moreno, H., de Brugada, I., & Hall, G. (2013). Chronic dietary choline supplementation modulates attentional change in adult rats. Behavioural brain research, 243, 278-285.
2. Blusztajn, J. K., & Mellott, T. J. (2013). Neuroprotective actions of perinatal choline nutrition. Clinical Chemistry and Laboratory Medicine, 51(3), 591-599.
3. Krzysztof Blusztajn, J., & J Mellott, T. (2012). Choline nutrition programs brain development via DNA and histone methylation. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents), 12(2), 82-94.
4. Biasi, E. (2011). The effects of dietary choline. Neuroscience bulletin, 27(5), 330-342.