NX5 Revolution™

$59.99$99.99

NITRIC OXIDE AMPLIFIER*

  • – Increases vascularity and muscle fullness*
  • – Inhibits the breakdown of Nitric Oxide to keep more of it active in the system*
  • – Reduces ammonia accrual and perception of fatigue during exercise*
  • – Improves time to exhaustion, VO2 max, and maximal workload*
  • – Stimulant free – stack with your favorite pre-workout

 

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Description

Have you ever wanted to put a Turbo Charger in your car to get a lot more power out of every turn of the engine? Many people may want this, but the cost and time of engine reconstruction is just too great for most. With NX5, you can get that boastful power with just a few capsules. Taken alone or in combination with an energy-boosting supplement, NX5 can take your pump to a new level. A carefully selected panel of ingredients ensures you get more pump out of every rep!

Arginine Matrix – Amplify vascularity and muscle fullness
Citrulline Malate – Increases nitric oxide production and vasodilation
Ornithine Orotate – Reduces ammonia accrual and perception of fatigue during exercise.
Norvaline – Inhibits the breakdown of Nitric Oxide to keep more of it active in the system
Taurine – Improves time to exhaustion, VO2 max, and maximal workload
Beet Juice Extract – Lowers the oxygen cost of exercise

Triggering muscle growth during training is all about engorging the muscle with blood. The more Nitric Oxide you can produce, the more blood will flood into the muscle. The ingredients in NX5 are formulated specifically to help boost these levels to their peak and beyond! Pick up your NX5 and add it to a pre-workout like RHINO BLACK or any other MuscleSport pre-workout and take your pumps into the stratosphere!

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredient Profile

NITRIC OXIDE MATRIX

Agmatine Sulfate:

Agmatine Sulfate helps improve nutrient partitioning which leads to an increase in muscle glycogen (carbs stored in muscle tissues) which then leads to more water retained WITHIN the muscle. This creates a fuller look to the muscles and a greater pump while hitting the iron.

  • Agmatine Sulfate also increases NO production by working as a competitive inhibitor of the enzyme NO Synthase.
  • There are studies to suggest that the nutrient partitioning effects of agmatine sulfate are possibly due to its ability to increase the insulin response to carbohydrates. This could be further explained by the increased blood flow to the muscle that occurs with increased NO production.
  • LH and GH levels have been shown to be increased through the effects of Agmatine Sulfate and its possible effects on the hypothalamus.
  • Agmatine has also been shown to manipulate pain receptors which may allow you to train past normal pain thresholds.

GlycoCarn (Glycine Propionyl-L-Carnitine HCL):

Glycocarn is a highly bioavailable form of Carnitine. Carnitine is crucial in muscle function by regulating energy flow across the cell membranes during strenuous activity.

  • Glycocarn can help increase nitric oxide levels. Increasing Nitric Oxide helps blood flow to organs and muscles and optimizes oxygen and nutrient delivery to the muscles.
  • All this can help to increase aerobic power, stamina, endurance, and recovery.
  • Jacobs et al. (2009) discovered that resistance trained males who supplemented with Glycocarn 90 minutes before exercise were able to increase peak power production (2-15%) and decrease lactic acid accumulation (15-17%).

NOX5 Arginine Matrix (Arginine AKG, Arginine HCL, Arginine Oratate, Arginine Ethyl Ester, Arginine HCL):

L-Arginine is a semi-essential amino acid and is a chemical precursor to nitric oxide (a blood vessel-widening agent).

  • When arginine enters the body it stimulates nitric oxide pathways. This process vasodilates (enlarges) blood vessels and helps deliver more of the much needed oxygen rich blood and nutrients to working muscles in order to achieve the pump and ultimately muscle growth.
  • Arginine also triggers the body to make protein and has been studied for healing wounds, bodybuilding, and preventing tissue degradation in people with critical illnesses.
  • A 2010 study conducted by Bailey et al. discovered supplemental arginine for 3 days was able to enhance nitric oxide production and decrease oxygen consumption (7%) while improving time to exhaustion by 25% in otherwise healthy men.

Ornithine Orotate:

Ornithine when bound by salt at the molecular level to Orotate (orotic acid) is much more bio-available than its HCL or free form.

  • Ornithine works in synergy with arginine in the metabolism of waste caused by intense exercise.
  • By increasing the nitric oxide production and decreasing waste you are able to train longer and decrease fatigue.
  • A 2008 study conducted by Sugino et al. discovered supplementation with ornithine was able to reduce perceptions of fatigue to 52% of placebo on a prolonged endurance test and was able to reduce ammonia accrual during exercise.

HICA:

HICA is short for DL-Alpha-Hydroxy-Isocaproic Acidand is the end result of leucine metabolism in human tissues.

  • Studies have shown that HICA can enhance anaerobic and aerobic performance as well as help to promote optimal gains in muscle mass and muscle fiber size.
  • However, the biggest benefit of HICA can be the reduction of delayed onset muscle soreness (DOMS).
  • Mero et. al (2010) discovered male soccer players who supplemented with HICA over a 4 week period were able to increase whole lean body mass and reduce soreness by 23% compared to placebo.

Citrulline Malate:

Citrulline Malate is a non-essential amino acid that eventually converts to nitric oxide. Nitric oxide is a vasodilator that can help to lower blood pressure and improve blood flow to both organs and muscles.

  • Studies have shown that Citrulline Malate enhances exercise tolerance by reducing levels of blood ammonia and lactate that are typically elevated during strenuous exercise.
  • This ingredient will allow you to train with less rest in between sets and elevate your endurance capacity.
  • A recent research study found individuals who consumed citrulline malate for 15 days were able to increase ATP production during exercise by 34% and improve phospho-creatine resynthesis after exercise by 20%.

Norvaline:

L-Norvaline is an analog of the branched chain amino acid, valine. It can be found in foods such as dairy, meat, grains, soy and peanuts. Since valine is an essential amino acid, L-Norvaline has to be obtained through the diet or supplementation, as the body cannot produce it.

  • Norvaline works in conjunction with arginine and other nitric oxide precursors by extending or prolonging their activity.
  • By prolonging this period more nitric oxide production can occur, even when the muscle cells supply of arginine starts to run low.
  • One study has shown L-Norvaline can effectively increase the production of NO by as much as 60%.

Taurine:

Taurine, has a myriad of benefits. From helping the body to metabolize fat, improving insulin sensitivity, raising testosterone levels, as an antioxidant, higher performance and quicker recovery during athletic training and increasing cardiovascular health… it goes without saying that Taurine is a great ingredient to have in your wheelhouse

  • Zhang et al. (2004) found that individuals who supplemented with taurine for 1 week before an exhaustive exercise bout significantly improved time to exhaustion, VO2 max, and maximal workload. It also decreased exercise induced DNA damage.

Beet Juice Extract:

Beta Vulgaris, also known as the common beet, has been shown to significantly reduce blood pressure. With this ingredient you can get a pump while lowering your blood pressure.

  • Beet has also been shown to lower the oxygen cost of exercise and improve exercise tolerance.
  • Lansley et al. (2011) found beet supplementation resulted an in mean power increase of 5%.  Other studies have also shown supplementation with beet can improve time trial performance by 3-15%.

OxoVanadium:

While operating in much the same way as vanadyl sulfate, OxoVanadium is an organic complex of glycine and vanadium and is much more readily absorbed by the body.

  • Vanadium has been shown to significantly improve glycemic control and thus improve liver and muscle sensitivity to insulin.
  • Vanadium may also be able to lower triglycerides (fat) in the body.
  • Cusi et al. found that subjects who supplemented with Vanadium for six weeks had less heptatic glucose production and less fasting blood glucose.
FAQs

Q: How should I take NX5 Revolution?
A: Take one serving (6 capsules) daily with 8-10 oz of water. For optimal performance take 20 minutes prior to your workout.

Q: What is vasodilation?
A: Vasodilation means enlargement of the blood vessels/veins. From a physiological perspective vasodilation provides more oxygen and nutrient blood to the working muscles which in turn may improve performance and cause a greater “pump”.

Q: What other MuscleSport products do you recommend stacking with NX5 Revolution?
A: We recommend stacking NX5 Revolution with one of our pre-workouts, like RHINO BLACK, or any other MuscleSport pre-workout and take your pumps into the stratosphere.

References

Agmatine Sulfate:
1. Ahn, S. K., S. Hong, et al. (2011). “Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.” Brain Res 1373: 48-54.
2. Arndt, M. A., V. Battaglia, et al. (2009). “The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis.” Am J Physiol Cell Physiol 296(6): C1411-1419.
3. Berkels, R., D. Taubert, et al. (2004). “Agmatine signaling: odds and threads.” Cardiovasc Drug Rev 22(1): 7-16.
4. Gao, Y., B. Gumusel, et al. (1995). “Agmatine: a novel endogenous vasodilator substance.” Life Sci 57(8): PL83-86.
5. Haenisch, B., I. von Kugelgen, et al. (2008). “Regulatory mechanisms underlying agmatine homeostasis in humans.” Am J Physiol Gastrointest Liver Physiol 295(5): G1104-1110.
6. Halaris, A. and J. Plietz (2007). “Agmatine: metabolic pathway and spectrum of activity in brain.” CNS Drugs 21(11): 885-900.
7. L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide.
8. Keynan, O., Mirovsky, Y., Dekel, S., Gilad, V. H., & Gilad, G. M. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc‐associated Radiculopathy. An Open‐label, Dose‐escalating Study Followed by a Randomized, Double‐blind, Placebo‐controlled Trial. Pain Medicine, 11(3), 356-368.

GlycoCarn (Glycine Propionyl-L-Carnitine HCL):
1. Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance. Jacobs PL, Goldstein ER. J Int Soc Sports Nutr. 2010 Oct 28;7:35. doi: 10.1186/1550-2783-7-35.
2. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Bloomer RJ, Tschume LC, Smith WA. Int J Vitam Nutr Res. 2009 May;79(3):131-41. doi: 10.1024/0300-9831.79.3.131.

NOX5 Arginine Matrix (Arginine AKG, Arginine HCL, Arginine Oratate, Arginine Ethyl Ester, Arginine HCL):
1. Tan, B., Yin, Y., Liu, Z., Li, X., Xu, H., Kong, X., … & Wu, G. (2009). Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino acids, 37(1), 169-175.
2. Huk, I., Nanobashvili, J., Neumayer, C., Punz, A., Mueller, M., Afkhampour, K., … & Patton, S. (1997). L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation, 96(2), 667-675.
3. Yao, K., Yin, Y. L., Chu, W., Liu, Z., Deng, D., Li, T., … & Wu, G. (2008). Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. The Journal of nutrition, 138(5), 867-872.
4. Jobgen, W., Meininger, C. J., Jobgen, S. C., Li, P., Lee, M. J., Smith, S. B., … & Wu, G. (2008). Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. The Journal of nutrition, jn-108.
5. Tseh, Wayland1; Cioci, Brian W.1; Morgan, Don W. FACSM2 The Effects of Arginine Alpha-Ketoglutarate Supplementation on Endurance-Trained Females http://journals.lww.com/acsm-msse/Citation/2008/05001/The_Effects_of_Arginine_Alpha_Ketoglutarate.2375.aspx
6. Thomas S. Rector, PhD; Alan J. Bank, MD; Kathleen A. Mullen, RN; Linda K. Tschumperlin, RN; Ronald Sih, MD; Kamalesh Pillai, MD; Spencer H. Kubo, MD Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients with Heart Failure http://circ.ahajournals.org/content/93/12/2135.full
7. E Morikawa, M A Moskowitz, Z Huang, T Yoshida, K Irikura and T Dalkara L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. http://stroke.ahajournals.org/content/25/2/429.short
8. S M Gardiner, A M Compton, T Bennett, R M Palmer, S Moncada Control of regional blood flow by endothelium-derived nitric oxide.

Ornithine Orotate:
1. Sugino, T., Shirai, T., Kajimoto, Y., & Kajimoto, O. (2008). L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutrition research, 28(11), 738-743.

HICA:
1. Mero, A. A., Ojala, T., Hulmi, J. J., Puurtinen, R., Karila, T. A., & Seppälä, T. (2010). Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes. J Int Soc Sports Nutr, 7(1), 8.
2. Mero, A. A., Ojala, T., Hulmi, J. J., Puurtinen, R., Karila, T. A., & Seppälä, T. (2010). Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes. J Int Soc Sports Nutr, 7(1), 8.
3. Tischler, M. E., Desautels, M., & Goldberg, A. L. (1982). Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle. J Biol Chem, 257(4), 1613-1621.
4. Jakobs, C., Sweetman, L., & Nyhan, W. L. (1984). Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Clinica chimica acta, 140(2), 157-166.

Citrulline Malate:
1. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine,36(4), 282-289.
2. Hickner, R. C., Tanner, C. J., Evans, C. A., Clark, P. D., Haddock, A., Fortune, C., … & Mccammon, M. (2006). L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Medicine and science in sports and exercise, 38(4), 660-666.
3. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
4. Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-citrulline-malate influence over branched chain amino acid utilization during exercise. European journal of applied physiology, 110(2), 341-351.

Norvaline:
1. Chang, C. I., Liao, J. C., & Kuo, L. (1998). Arginase modulates nitric oxide production in activated macrophages. American Journal of Physiology-Heart and Circulatory Physiology, 274(1), H342-H348.

Taurine:
1. Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., Yamagami, T., Liu, Z., & Qi, B. (2004). Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino acids, 26(2), 203-207.
2. BOUCHAMA, A., YUSUF, A., AL-SEDAIRY, S. U. L. T. A. N., & EL-YAZIGI, A. D. N. A. N. (1993). Alteration of taurine homeostasis in acute heatstroke.Critical care medicine, 21(4), 551-554.
3. Gwacham, N., & Wagner, D. R. (2012). Acute effects of a caffeine-taurine energy drink on repeated sprint performance of American college football players. Int J Sport Nutr Exerc Metab, 22(2), 109-116.
4. Warskulat, U., Brookmann, S., Felsner, I., Brenden, H., Grether‐Beck, S., & Häussinger, D. (2008). Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts. Experimental dermatology, 17(12), 1031-1036.

Beet Juice Extract:
1. Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., … & Jones, A. M. (2011). Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.Journal of Applied Physiology, 110(3), 591-600.
2. Cermak, N. M., Gibala, M. J., & Van Loon, L. J. (2012). Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. International Journal of Sport Nutrition andExercise Metabolism,22(1), 64.

OxoVanadium:
1. Jacques-Camarena, O., González-Ortiz, M., Martínez-Abundis, E., López-Madrueño, J. P., & Medina-Santillán, R. (2008). Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance. Annals of Nutrition and Metabolism, 53(3-4), 195-198.
2. Cohen, N., Halberstam, M., Shlimovich, P., Chang, C. J., Shamoon, H., & Rossetti, L. (1995). Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.Journal of Clinical Investigation, 95(6), 2501.
3. Cusi, K., Cukier, S., DeFronzo, R. A., Torres, M., Puchulu, F. M., & Redondo, J. P. (2001). Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes 1. The Journal of Clinical Endocrinology & Metabolism, 86(3), 1410-1417.

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Warning

While not illegal, some of the ingredients found in this product could lead to a false positive drug test and may also be banned by WADA or other professional organizations such as the NCAA. If you are a professional, college, or amateur athlete whose given sports conduct in and out of competition random drug screens is it highly recommended you check with the appropriate person before taking this product.