Joint Revolution™

$59.99

MUSCLE AND JOINT SUPPORT

  • – Assists with the growth, repair, and maintenance of cartilage
  • – Helps joint pain, improves joint stiffness, and decreases the symptoms of osteoarthritis
  • – Assists with improving joint flexibility and the formation of collagen
  • – Plays a key role in cushioning and lubricating areas such as joints and muscles
  • – Decreases swelling and inflammation in soft tissue and joint disorders

 

SKU: 1146 Category:
Description

Exercising hour after hour, week after week, year after year, can often cause excessive wear and tear on your joints and muscles. Over time this “wear and tear” can often lead to more serious issues such as musculoskeletal injuries, joint inflammation and stiffness, and in the worst case scenario symptoms of osteoarthritis can appear. These issues can often have a crippling effect when it comes to further exercise and activities of daily living. This is why MuscleSport developed Joint Revolution™…a full muscle and joint support matrix containing ingredients that may help protect joints and muscles, reduce inflammation, and minimize the stress exercise puts on your body.

Glucosamine Sulfate – A natural component in the growth, repair, and maintenance of cartilage. It may also assist with the slowing down of joint damage.
Chondroitin Sulfate – Helps joint pain, improves joint stiffness, and decreases the symptoms of osteoarthritis.
MSM – Assists with improving joint flexibility, the formation of collagen, and reducing joint stiffness and swelling.
Hyaluronic Acid – Plays a key role in cushioning and lubricating areas such as joints and muscles.
Bromelain – Decreases swelling and inflammation in soft tissue and joint disorders. Also the combination of bromelain and glucosamine provides relief from joint stiffness.

Like a fine tuned machine, your body is a system of many parts that all work together to create movement. When everything functions well there are no issues. However, any one problem (i.e. joint inflammation) in the entire system can have disastrous consequences as a whole. As the saying goes “An ounce of prevention is worth a pound of cure. ” From top to bottom the ingredients found in Joint Revolution™ will support optimal joint and muscle health and may help prevent the ill effects of bodily wear and tear. Think of it as an insurance policy for your body.

Ingredient Profile

Glucosamine Sulfate:

Glucosamine Sulfate is an amino sugar and a precursor in the biochemical synthesis of glycosylated proteins and lipids found in the body.

  • Glycosaminoglycans are highly polar, and attract water which in turn is useful for the body to use as a lubricant component of cellular fluidity and joint mobility.
  • Glucosamine produced in the body is a natural component in the growth, repair, and maintenance of cartilage. It may also assist with the slowing down of joint damage.
  • Glucosamine with the combination of chondroitin has shown to assist with pain relief in association with arthritis.
  • A recent study from the American Journal of Epidemiology suggest that glucosamine and chondroitin supplements are associated with reduced inflammation.

Chondroitin Sulfate:

Chondroitin Sulfate is a sulfated glycosaminoglycan which is an important structural component of cartilage.

  • Chondroitin provides the building blocks for the synthesis of proteoglycans including sulfate incorporation and assists with resistance to compression alongside cartilage.
  • Chondroitin may help joint pain, improve joint stiffness, and decrease the symptoms of osteoarthritis.

MSM:

Methylsulfonylmethane (MSM) is a major sulfur-containing compound commonly found in the diet and assists with the formation of antioxidants.

  • It is a clear sulfur donator to antioxidants like glutathione.
  • Alongside being a sulfur donator to antioxidants, MSM assists in the breakdown of unhealthy calcium deposits for which some of these deposits can be a cause of joint issues.
  • MSM can assist with improving joint flexibility, reduce joint stiffness and swelling, and assist in the formation of collagen.
  • A recent study in Japan on rats showed in an accepted human osteoarthritis model showed decreased degeneration of cartilage at the joint surface in the knee joints

Hyaluronic Acid:

Hyaluronic Acid also known as hyaluronan or hyaluronate is a mucopolysaccharide occurring naturally throughout the body.

  • This incredibly versatile molecule binds to water giving it an almost “jello” like viscosity.
  • It plays a key role in cushioning and lubricating areas such as joints, eyes, and muscles.
  • A common forgotten aspect of Hyaluronic acid is its powerful antioxidant properties and its ability to protect against free-radical damage to cells.
  • It may also help decrease symptoms of osteoarthritis.

Orthosilicic Acid:

Orthosilicic Acid (OSA) is a type of silicic acid that naturally occurs in water, seawater, and certain beverages (like beer).

  • It is often referred to as “soluble silica” because Orthosilicic Acid is a dietary form of silicon (a mineral that is involved in the creation of collagen and bones).
  • Research on OSA has shown it may improve bone and joint health.
  • In a 2008 study, 136 women with osteopenia took OSA along with calcium and vitamin D, or a simple placebo every day for a year. After the full year was completed, participants given OSA had shown greater improvements in bone formation.
  • Scientists attributed this to OSA’s ability to stimulate the production of collagen (a protein that is found in connective tissue) and in promoting the development of “bone-forming cells.”

ANTI-INFLAMMATORY COMPLEX

Quercitin:

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonoid. It possesses anti-inflammatory and antioxidant properties.

  • Quercetin is also neuroactive, with some of the same abilities as caffeine but less potent.
  • Quercetin acts as a estrogen modulator, having the ability to regulate estrogen and androgen levels.
  • Quercetin is also able to prevent testicular damage from Dioxins and thus prevent a decline in testosterone levels.

Bromelain:

Bromelain is a collection of proteolytic enzymes extracted from the pineapple stems and leaves.

  • The combination of bromelain and glucosamine provides relief from joint stiffness.
  • Studies have shown that bromelain may decrease swelling and inflammation in soft tissue and joint disorders.
  • It has been used as an alternative treatment to NSAIDs for osteoarthritis.
  • A study done in 2002, showed that subjective symptom assessment in terms of stiffness, physical function, and psychological well-being were improved on bromelain.
FAQs

Q: What is the best way to take Joint Revolution?
A: Take One Serving (4 Capsules) in the AM with food.

Q: Does exercise cause excessive wear and tear on joints and muscles?
A: In most cases it does not and actually improves joint and muscle health. However, joint misalignment, poor biomechanics, and weakened muscles can often cause inflammation and the “wear and tear” on muscles, joints, and cartilage.

Q: What other MuscleSport products do you recommend stacking with Joint Revolution?
A: To promote full body health we recommend stacking Joint Revolution with Life Shield, Liver-Pro Revolution, Multi Vita Revolution, and Adrenal Revolution.

References

Glucosamine Sulfate:
1. Herrero‐Beaumont, G., Ivorra, J. A. R., del Carmen Trabado, M., Blanco, F. J., Benito, P., Martín‐Mola, E., … & Araujo, D. (2007). Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator. Arthritis & Rheumatism, 56(2), 555-567.
2. Reginster, J. Y., Deroisy, R., Rovati, L. C., Lee, R. L., Lejeune, E., Bruyere, O., … & Gossett, C. (2001). Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. The Lancet, 357(9252), 251-256.
3. Ostojic, S. M., Arsic, M., Prodanovic, S., Vukovic, J., & Zlatanovic, M. (2007). Glucosamine administration in athletes: effects on recovery of acute knee injury. Research in Sports Medicine, 15(2), 113-124.
4. Yoshimura, M., Sakamoto, K., Yamamoto, T., Ishida, K., Yamaguchi, H., & Nagaoka, I. (2009). Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. International journal of molecular medicine, 24(4), 487-494.

Chondroitin Sulfate:
1. Conte, A., Volpi, N., Palmieri, L., Bahousb, I., & Roncac, G. (1995). Biochemical and Pharmacokinetic Aspects of Oral Treatment with Chondroitin Sulfate.
2. Deal, C. L., & Moskowitz, R. W. (1999). Nutraceuticals as therapeutic agents in osteoarthritis: the role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheumatic Disease Clinics of North America, 25(2), 379-395.
3. Bruyere, O., & Reginster, J. Y. (2007). Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs & aging, 24(7), 573-580.
4. Black, C., Clar, C., Henderson, R., MacEachern, C., McNamee, P., Quayyum, Z., … & Thomas, S. (2009). The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.
5. Reichenbach, S., Sterchi, R., Scherer, M., Trelle, S., Bürgi, E., Bürgi, U., … & Jüni, P. (2007). Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Annals of internal medicine, 146(8), 580-590.

MSM:
1. Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., … & Debi, R. (2011). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC complementary and alternative medicine, 11(1), 1.
2. Kalman, D. S., Feldman, S., Scheinberg, A. R., Krieger, D. R., & Bloomer, R. J. (2012). Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. Journal of the International Society of Sports Nutrition, 9(1), 1-11.
3. Barmaki, S., Bohlooli, S., Khoshkhahesh, F., & Nakhostin-Roohi, B. (2012). Effect of methylsulfonylmethane supplementation on exercise-Induced muscle damage and total antioxidant capacity. The Journal of sports medicine and physical fitness, 52(2), 170-174.
4. Ezaki, J., Hashimoto, M., Hosokawa, Y., & Ishimi, Y. (2013). Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. Journal of bone and mineral metabolism, 31(1), 16-25.

Hyaluronic Acid:
1. Holmes, M. W. A., Bayliss, M. T., & Muir, H. (1988). Hyaluronic acid in human articular cartilage. Age-related changes in content and size.Biochemical Journal, 250(2), 435-441.
2. Kalman, D. S., Heimer, M., Valdeon, A., Schwartz, H., & Sheldon, E. (2008). Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal, 7(1), 1.
3. Paker, N., Tekdös, D., Kesiktas, N., & Soy, D. (2006). Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study. Advances in therapy, 23(2), 342-353.
4. Petrella, R. J. (2005). Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience. American journal of physical medicine & rehabilitation, 84(4), 278-283.
5. Benfield, P., & Goa, K. L. (1994). Hyaluronic Acid: A review of its Pharmacology and Use as a Surgical Aid in Ophtalmology and its Therapeutic Potential in Joint Disease and Wound Healing. Drugs, 47(3), 536-66.

Orthosilicic Acid:
1. Spector, T. D., Calomme, M. R., Anderson, S. H., Clement, G., Bevan, L., Demeester, N., … & Powell, J. J. (2008). Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial.BMC Musculoskeletal Disorders, 9(1), 1.
2. Calomme, M., Geusens, P., Demeester, N., Behets, G. J., D’Haese, P., Sindambiwe, J. B., … & Berghe, D. V. (2006). Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. Calcified tissue international, 78(4), 227-232.
3. Macdonald, H. M., Hardcastle, A. C., Jugdaohsingh, R., Fraser, W. D., Reid, D. M., & Powell, J. J. (2012). Dietary silicon interacts with oestrogen to influence bone health: evidence from the Aberdeen Prospective Osteoporosis Screening Study. Bone, 50(3), 681-687.
4. Kim, M. H., Bae, Y. J., Choi, M. K., & Chung, Y. S. (2009). Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption. Biological trace element research, 128(3), 239-247.

Quercitin:
1. Guennen, M., Gillum, T., Dokladny, K., Bedrick, E., Schneider, S., & Moseley, P. (2011). Thermotolerance and heat acclimation may share a common mechanism in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 301(2), R524-R533.
2. Boots, A. W., Drent, M., de Boer, V. C., Bast, A., & Haenen, G. R. (2011). Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clinical nutrition, 30(4), 506-512.
3. Edwards, R. L., Lyon, T., Litwin, S. E., Rabovsky, A., Symons, J. D., & Jalili, T. (2007). Quercetin reduces blood pressure in hypertensive subjects.The Journal of nutrition, 137(11), 2405-2411.
4. Talirevic, E., & Sehovic, J. (2012). Quercetin in the treatment of dyslipidemia. Medical Archives, 66(2), 87.

Bromelein:
1. Walker, A. F., Bundy, R., Hicks, S. M., & Middleton, R. W. (2002). Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine, 9(8), 681-686.
2. Brien, S., Lewith, G., Walker, A., Hicks, S. M., & Middleton, D. (2004). Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-based complementary and alternative medicine, 1(3), 251-257.
3. Brien, S., Lewith, G., Walker, A. F., Middleton, R., Prescott, P., & Bundy, R. (2006). Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM,99(12), 841-850.
4. Walker, A. F., Bundy, R., Hicks, S. M., & Middleton, R. W. (2002). Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine, 9(8), 681-686.

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