Description

Hormones are the most impactful molecules for augmenting body composition, performance, many other bodily attributes. Estrogen is one such hormone that, when increased, can cause bloating and swelling, altered sex drive, mood swings, weight gain, and even other unwanted effects. Unnatural estrogens are becoming more widespread in the modern world, and natural estrogen levels can increase as a result of certain environments or other physiological stressors. Some of which also increase cortisol, the stress hormone, further disrupting natural endocrine function, and reduce testosterone. Estro-X™ was designed to combat high estrogen levels, restore optimal testosterone concentrations, and manage cortisol.

• KSM-66® supplementation helps increase testosterone in men and reduce stress & cortisol in both men and women.
• Green Tea helps maintain more active testosterone levels by reducing its excretion in the urine.
• SerinAid® reduces cortisol and helps manage physiological responses to stressful situations.
• Atractylodes Macrocephala acts as an aromatase inhibitor, reducing testosterone’s conversion to estrogen.
• DIIM helps detoxify estrogens, limiting their ability to stimulate estrogenic effects.

Estro-X™ is an all-in-one formula sure to improve levels of all three of these key hormones.

Supplement Facts

Ingredient Profile

KSM-66

KSM-66® Ashwagandha

Ashwagandha is an ancient ayurvedic herb and adaptogen. KSM-66® is a standardized version that can be trusted to contain necessary quantities of active ingredients.

• Supplementation with Ashwagandha has been demonstrated to improve testosterone levels in healthy men.
• Increased testosterone by Ashwagandha is thought to be the underlying mechanism for improved strength and lean mass and decreased fat mass after Ashwagandha supplementation.
• Doubles as a potent anxiolytic agent to reduce cortisol and anxiety.

Green Tea Leaf Extract

Green Tea contains many polyphenols which are capable of influencing body fat regulation.

• Reduces testosterone conjugation to impotent testosterone glucuronide. In other words, keeps more testosterone around as active, anabolic testosterone.
• Green tea can reduce glucose absorption when consumed before meals, decreasing caloric loads of meals.
• Has evidence of enhancing fat oxidation.
• Boosts metabolic rate, especially when paired with caffeine, to burn more calories.
• Early evidence of one polyphenol in green tea for decreasing myostatin and increasing muscle gain.

SerinAid

SerinAid® phosphatidylserine is a specialized phospholipid with many benefits related to brain and nervous system function, including reduced stress.

• PS may improve memory and lower cortisol levels in the body.
• Parker et al. (2011) discovered subjects who supplemented with PS over two weeks were able to increase the speed of mathematical calculations (20%) and improve answer accuracy (13%) compared to placebo.

Atractylodes Macrocephala

Also known as bai-zhu, Atractylodes macrocephala is a plant with anti-estrogen potential.

• Contains aromatase inhibitors
• Aromatase inhibition stops the conversion of testosterone to estrogen
• This helps to keep testosterone levels higher while estrogen levels are suppressed

Diindolylmethane

DIM is a molecule that consists of two indole groups attached to a methine group. It is commonly found in broccoli and holds promise as an aromatase inhibitor.

• DIM has potent effects on estrogen metabolism and is able to keep the body relatively balanced by preventing either drastic increases or decreases in estrogen.
• DIM can both inhibit the aromatase enzyme (and prevent the conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body.

FAQs

Q: What is the best way to use Estro-X™?

A: As a dietary supplement, take 1 serving (3 capsules) once daily.

Q: Can Estro-X™ be used with any other products?

A: Yes! For the best improvements in testosterone, estrogen, and cortisol profiles, stack Estro-X™ with Test Revolution BLACK.

References

KSM-66® Ashwagandha

1. Raut, A. A., Rege, N. N., Tadvi, F. M., Solanki, P. V., Kene, K. R., Shirolkar, S. G., ... & Vaidya, A. B. (2012). Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. Journal of Ayurveda and integrative medicine, 3(3), 111.
2. Sandhu, J. S., Shah, B., Shenoy, S., Chauhan, S., Lavekar, G. S., & Padhi, M. M. (2010). Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. International journal of Ayurveda research, 1(3), 144.
3. Ahmad, M. K., Mahdi, A. A., Shukla, K. K., Islam, N., Rajender, S., Madhukar, D., ... & Ahmad, S. (2010). Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertility and sterility, 94(3), 989-996.
4. Gupta, A., Mahdi, A. A., Shukla, K. K., Ahmad, M. K., Bansal, N., Sankhwar, P., & Sankhwar, S. N. (2013). Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. Journal of ethnopharmacology, 149(1), 208-214.
5. Mahdi, A. A., Shukla, K. K., Ahmad, M. K., Rajender, S., Shankhwar, S. N., Singh, V., & Dalela, D. (2011). Withania somnifera improves semen quality in stress-related male fertility. Evidence-Based Complementary and Alternative Medicine, 2011.
6. Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 43.

Green Tea Extract

1. Jenkinson, C., Petroczi, A., Barker, J., & Naughton, D. P. (2012). Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. Steroids, 77(6), 691-695.
2. Dellalibera, O., Lemaire, B., & Lafay, S. (2006). Svetol, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie, 4(4), 194-197.
3. Shimoda, H., Seki, E., & Aitani, M. (2006). Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC complementary and alternative medicine, 6(1), 9.
4. Ochiai, R., Jokura, H., Suzuki, A., Tokimitsu, I., Ohishi, M., Komai, N., ... & Ogihara, T. (2004). Green coffee bean extract improves human vasoreactivity. Hypertension Research, 27(10), 731-737.
5. Thom, E. (2007). The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. Journal of International Medical Research, 35(6), 900-908.
6. Watanabe, T., Arai, Y., Mitsui, Y., Kusaura, T., Okawa, W., Kajihara, Y., & Saito, I. (2006). The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clinical and experimental hypertension, 28(5), 439-449.

Phosphatidylserine

1. Kingsley, M. I., Miller, M., Kilduff, L. P., McENENY, J. A. N. E., & Benton, D. (2006). Effects of phosphatidylserine on exercise capacity during cycling in active males. Medicine and science in sports and exercise, 38(1), 64-71.
2. Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., & Jäger, R. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition,5(1), 1-6.
3. Parker, A. G., Gordon, J., Thornton, A., Byars, A., Lubker, J., Bartlett, M., ... & Greenwood, M. (2011). The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. Journal of the International Society of Sports Nutrition, 8(1), 16.
4. Carter, J., & Greenwood, M. (2015). Phosphatidylserine for the Athlete.Strength & Conditioning Journal, 37(1), 61-68. 4. Kingsley, M. (2006). Effects of phosphatidylserine supplementation on exercising humans. Sports medicine, 36(8), 657-669.

Atractylodes Macrocephala

1. Jiang, H., Shi, J., & Li, Y. (2011). Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules, 16(4), 3146-3151.
2. Weng, Q., Cao, Z. F., Yu, Y. W., Lv, X. L., Qu, F., & Zhou, J. (2016). The effects of extracts of atractylodes macrocephala koidz combined with transcutaneous electrical acupoint stimulation in treating the ovariectomized female rats. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 133-139.
3. Zhang, C. Z., Wang, S. X., Zhang, Y., Chen, J. P., & Liang, X. M. (2005). In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Journal of Ethnopharmacology, 98(3), 295-300.

Diindolylmethane

1. Lo, R., & Matthews, J. (2010). A New Class of Estrogen Receptor Beta–Selective Activators. Molecular interventions, 10(3), 133.
2. Leong, H., Riby, J. E., Firestone, G. L., & Bjeldanes, L. F. (2004). Potent ligand-independent estrogen receptor activation by 3, 3′-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Molecular Endocrinology, 18(2), 291-302.
3. Leong, H., Firestone, G. L., & Bjeldanes, L. F. (2001). Cytostatic effects of 3, 3′-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-α expression. Carcinogenesis, 22(11), 1809-1817.
4. Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., & Van den Berg, M. (2001). 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicological sciences, 61(1), 40-48.
5. Safe, S., Wang, F., Porter, W., Duan, R., & McDougal, A. (1998). Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology letters, 102, 343-347.

WARNING

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm - www.P65warnings.ca.gov/