Picture this scenario. You head to your favorite supplement store in search of a pre workout that will help take your training to the next level. As you walk through the door you are immediately lost in a sea of colorful canister’s whose labels all promise the same thing.
Mind blowing pumps. High octane energy. Tunnel vision focus. All of it sounds too good to be true. You decide on the one highly recommended by a bro you watched on YouTube.
The next day, you eagerly head off to tackle an intense training session fueled by a concoction that has guaranteed you will have the best workout of your life. As you warm-up, you start to “feel” something.
Thinking that your pre workout has kicked in, you hit your session with full intensity only to be stopped dead in your tracks 15 minutes later. Zero energy. Zero focus. Zero Pump. 100% disappointment.
The realization sets in that the only thing provided by this so-called “pre workout” was hype and empty promises. Unfortunately, the above scenario plays out day after day.
The culprits? A combination of ineffective ingredients and a bottomless marketing budget built on pure speculation. It’s time to stop buying into the hype and put your trust in a pre workout that actually WORKS.
That is why MuscleSport developed RHINO 2.0; a revolutionary pre workout with an ultra-concentrated blend of energy, pump, and focus ingredients such as:
- Caffeine Matrix – Improves energy, focus, and power all without the typical caffeine crash
- Nitrosigine® – Maximal and long lasting vasodilation for HUGE pumps from the most thoroughly vetted source of arginine.
- Hordenine, Higenamine, & Halostachine – Powerful stimulants that can amplify energy, enhance mental clarity, and burn fat.
- Agmatine Sulfate – Manipulates pain receptors helping you train past normal pain thresholds.
Rhino 2.0 has everything you need in one comprehensive formula and nothing you don’t. While other inferior pre workouts try to make you “feel” something they fail to prepare you physiologically and psychologically for your upcoming workout.
The synergistic combination of ingredients found in Rhino 2.0's three different complexes address critical areas necessary to maximize performance and ultimately have you prepared to dominate your next training session.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
RHINO MODE ENERGY COMPLEX
Choline Complex (CDP Choline/Choline Bitartrate):
Choline is an essential nutrient for brain health and synaptic plasticity.
- Choline improves structural integrity, signaling capacity and the fluidity of neural membranes. It’s estimated that close to 90% of the population does not get the recommended amount of choline daily.
- It has been shown that a dose of 500mg of Choline can boost focus, mood and concentration abilities.
- This is tantamount to pushing through your workout. Utilizing this effectively dosed compound, you will be able to focus on taking less rest or being distracted during you training. Giving your 110% will really be your 110%.
- A study conducted by Sun et al. (1999) reported that subjects who supplemented with choline for 4 weeks improved learning performance and memory compared to a placebo group.
Tri-Caffeine Matrix (Caffeine Anhydrous, DiCaffeine Malate, Caffeine Citrate):
This blend of caffeine helps to provide effectively dosed stimulation for your training and not keep you up all night long.
- It is also formulated to help fight that horrible crash you might experience with stimulated laden pre-workouts.
- Multiple studies have confirmed can improve muscular endurance and power, focus and cognitive performance, and improve energy levels. Caffeine has also been shown to have a thermogenic effect (heating/calorie burning) at rest and may increase the use of fats for fuel during exercise.
- Doherty and Smith performed a meta-analysis of caffeine's effects on perceived exertion and found a 5.6% decrease in RPE (rating of perceived exertion) during exercise. This means exercise may feel easier at higher effort levels when supplementing with caffeine.
3H-S STIMULANT COMPLEX
Extracted from the roots of sprouted barley, hordenine has an adrenaline-like effect stemming from its ability to release noradrenaline.
- This increases heart rate and blood flow.
- The adrenaline effect is long lasting and does not fade early in your workouts. This will create a boost in athletic performance throughout your entire workout.
- Hordenine may also increase peripheral blood flow volume and have a positive inotropic effect (increases the strength of contraction) upon the heart.
Higenamine Hydrochloride is a proven beta 1 and 2 adrenergic agonists; meaning that when found in a pre-workout it can help improve focus, enhance mental clarity, increase energy, and burn body fat.
- Higenamine has also been shown to open up lung capacity by relaxing the trachea, allowing more oxygen to get into your body during training.
- While most stimulants do the opposite of vascular relaxation and vasodilation, higenmanine has been shown to do just this. It also works synergistically with agmatine sulfate that is in RHINO REVOLUTION 2.0.
Best known as an alternative for ephedrine, Synephrine has several of the same benefits of ephedrine but not nearly the same side-effects.
- Synephrine can reduce appetite, increase alertness, burn fat, increase metabolism and increase energy.
- However, like ephedrine, if you take this too close to bedtime - it could create some insomnia.
- Stohs et al. (2011) found that a single dose of synephrine given to healthy subjects in a rested state increased resting metabolic rate without any negative influence on blood pressure or cognition.
Another ingredient that shares similarities with beta-adrenergic receptor agonists. This means Halostachine will stimulate the beta receptors which are found on fat cells. This stimulation causes the fat to be burned as energy.
- In an in vitro study of the pharmacodynamics and Structure-Activity Relationship (SAR) of various epinephrine-like compounds, halostachine was demonstrated to be 19% as effective as epinephrine in activating beta2 receptors.
RHINO MODE NITRO COMPLEX
Inositol arginine silicate (NITROSIGINE):
Arginine (NITROSIGINE) is a precursor to nitric oxide and expands blood vessels to optimize blood flow. Silicate is contained within the walls of the arteries to help maintain their structural integrity.
- These ingredients work in synergy to help increase the blood flow and the structural integrity of the artery walls.
- Preclinical data has shown that Nitrosigine is superior to standard arginine… with 2x the blood flow in vasodilatation response.
Tauric acid, has a myriad of benefits. From helping the body to metabolize fat, improving insulin sensitivity, raising testosterone levels, as an antioxidant, higher performance and quicker recovery during athletic training and increasing cardiovascular health… it goes without saying that tauric acid is a great ingredient to have in your wheelhouse
- Zhang et al. (2004) found that individuals who supplemented with taurine for 1 week before an exhaustive exercise bout significantly improved time to exhaustion, VO2 max, and maximal workload. It also decreased exercise-induced DNA damage.
Agmatine Sulfate helps improve nutrient partitioning which leads to an increase in muscle glycogen (carbs stored in muscle tissues) which then leads to more water retained WITHIN the muscle. This creates a fuller look to the muscles and a greater pump while hitting the iron.
- Agmatine Sulfate also increases NO production by working as a competitive inhibitor of the enzyme NO Synthase.
- There are studies to suggest that the nutrient partitioning effects of agmatine sulfate are possibly due to its ability to increase the insulin response to carbohydrates. This could be further explained by the increased blood flow to the muscle that occurs with increased NO production.
- LH and GH levels have been shown to be increased through the effects of Agmatine Sulfate and its possible effects on the hypothalamus.
- Agmatine has also been shown to manipulate pain receptors which may allow you to train past normal pain thresholds.
Niacin is a form of Vitamin B3. Vitamin B3 is found in many foods including yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains.
- Niacin promotes health in the nervous system, digestive system, skin, hair and eyes.
- Niacin has long been used to increase high-density lipoprotein (HDL), or the "good," cholesterol. HDL cholesterol helps sweep up low-density lipoprotein (LDL), or the "bad," cholesterol, in your bloodstream.
- Niacin also helps improve liver function, metabolize food, and helps your adrenal glands produce sex and stress hormones.
- Niacin is also known for increasing blood circulation.
- Blond et al. discovered in 20 men without diabetes but with dyslipidemia, 2g niacin supplementation over the course of eight weeks promoted a reduction in triglycerides (28%) and vLDL (68%) while increasing HDL cholesterol (17%).
Has been shown to reduce blood sugar levels as well as raising insulin and hemoglobin levels to normal at the same time. It also shows a cognitive benefit by helping to offer protection against free radicals damage to the brain… which can lead to a greater focus
- When caffeine (another ingredient found in RHINO REVOLUTION 2.0) is combined with pterostilbene it improves long-lasting focus and energy. This combination lasts 8 times longer than normal caffeine, without the added crash at the end.
- Pterostilbene also supports anti-oxidant and heart-healthy benefits.
Q: What is the best way to take Rhino 2.0?
A: As a dietary supplement, mix one scoop of Rhino 2.0 into 6-12 ounces of water and consume 20-30 minutes prior to training.
Q: What other MuscleSport products do you recommend stacking with Rhino 2.0?
Q: I see a full serving of Rhino 2.0 has 400mg of caffeine. Is that amount safe?
A: Generally speaking, yes. A large review by the European Food Safety Authority concluded that a daily safe dose of 400mg is safe for adults.
Because some sources of caffeine in Rhino 2.0 are from Infinergy and Caffeine Citrate, there is about 350mg total caffeine.
We suggest not taking any other stimulants (like coffee) on the days you take Rhino 2.0. We also recommend starting with a half scoop to assess your tolerance before moving on to a full scoop.
1. Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25-37.
2. Stout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D., Costa, P., Hoffman, J. R., ... & O’kroy, J. (2007). Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino acids,32(3), 381-386.
3. Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., ... & Stout, J. R. (2009). Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. Journal of the International Society of Sports Nutrition, 6(1), 1-9.
4. Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. Journal of Applied Physiology, 109(4), 1096-1101.
5. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., ... & Campbell, B. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12(1), 1-14.
1. Moreno, H., de Brugada, I., & Hall, G. (2013). Chronic dietary choline supplementation modulates attentional change in adult rats. Behavioural brain research, 243, 278-285.
2. Blusztajn, J. K., & Mellott, T. J. (2013). Neuroprotective actions of perinatal choline nutrition. Clinical Chemistry and Laboratory Medicine, 51(3), 591-599.
3. Krzysztof Blusztajn, J., & J Mellott, T. (2012). Choline nutrition programs brain development via DNA and histone methylation. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents), 12(2), 82-94.
4. Biasi, E. (2011). The effects of dietary choline. Neuroscience bulletin, 27(5), 330-342.
1. Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., ... & Wildman, R. (2010). International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr, 7(1), 5.
2. Spriet, L. L. (1995). Caffeine and performance. International journal of sport nutrition, 5, S84-S84.
3. Beck, T. W., Housh, T. J., Schmidt, R. J., Johnson, G. O., Housh, D. J., Coburn, J. W., & Malek, M. H. (2006). The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. The Journal of Strength & Conditioning Research, 20(3), 506-510.
4. McLellan, T. M., Kamimori, G. H., Voss, D. M., Tate, C., & Smith, S. J. (2007). Caffeine effects on physical and cognitive performance during sustained operations. Aviation, space, and environmental medicine, 78(9), 871-877.
5. Lieberman, H. R., Tharion, W. J., Shukitt-Hale, B., Speckman, K. L., & Tulley, R. (2002). Effects of caffeine, sleep loss, and stress on cognitive performance and mood during US Navy SEAL training. Psychopharmacology, 164(3), 250-261.
6. Costill, D. L., Dalsky, G. P., & Fink, W. J. (1977). Effects of caffeine ingestion on metabolism and exercise performance. Medicine and science in sports, 10(3), 155-158.
7. Kovacs, E. M., Stegen, J. H., & Brouns, F. (1998). Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and Performance. Journal of Applied physiology, 85(2), 709-715.
1. Barwell, C. J., Basma, A. N., Lafi, M. A. K., & Leake, L. D. (1989). Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. Journal of pharmacy and pharmacology, 41(6), 421-423.
2. Hapke, HJ, Strathmann, W. (1995). Pharmacological effects of Hordenine. Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32.
3. Frank, M., Weckman, T. J., Wood, T., Woods, W. E., TAI, C. L., CHANG, S. L., ... & Tobin, T. (1990). Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. Equine veterinary journal, 22(6), 437-441.
1. Bai, G., Yang, Y., Shi, Q., Liu, Z., & Zhang, Q. (2008). Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1. Acta Pharmacologica Sinica, 29(10), 1187-1194.
2. Kam, S. C., Do, J. M., Choi, J. H., Jeon, B. T., Roh, G. S., Chang, K. C., & Hyun, J. S. (2012). The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. International journal of impotence research, 24(2), 77-83.
3. Tsukiyama, M., Ueki, T., Yasuda, Y., Kikuchi, H., Akaishi, T., Okumura, H., & Abe, K. (2009). Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta medica, 75(13), 1393-1399.
4. Zhou, S. J., & Du, G. Y. (2003). [Effects of higenamine on the cardio-circulatory system]. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, 28(10), 910-913.
5. Kang, Y. J., Lee, Y. S., Lee, G. W., Lee, D. H., Ryu, J. C., Yun-Choi, H. S., & Chang, K. C. (1999). Inhibition of activation of nuclear factor κB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. Journal of Pharmacology and Experimental Therapeutics, 291(1), 314-320.
6. Pyo, M. K., Lee, D. H., Kim, D. H., Lee, J. H., Moon, J. C., Chang, K. C., & Yun-Choi, H. S. (2008). Enantioselective synthesis of (R)-(+)-and (S)-(−)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.Bioorganic & medicinal chemistry letters, 18(14), 4110-4114.
1. Stohs, S. J., et al. Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. Int J Med Sci. 8(4):295-301, 2011.
2. Stohs, S. J., et al. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci. 9(7):527-38, 2012.
3. Sale, C., et al. Metabolic and physiological effects of ingesting extracts of bitter orange, green tea and guarana at rest and during treadmill walking in overweight males. International Journal of Obesity 1:10, 2006.
4. Gougeon, R., et al. Increase in the thermic effect of food by adrenergic amines extracted from Citrus aurantium. Obesity Research 13(7):1187-94, 2005.
5. Zenk, J. L., et al. Effect of multi-ingredient weight-loss product on metabolic rate and body composition. Nutrition 21:179-185, 2005.
6. Preuss, H. G., et al. Citrus aurantium as a thermogenic, weight reduction replacement for ephedra: An overview. Journal of Medicine 33:1-4, 2002.
7. Stohs, S. J., et al. A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxidative Medicine and Cellular Longevity, 2001.
8. Stohs, S. J., et al. The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytotherapy Research, 2011.
9. Kaats, G.R. et al. A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food and Chemical Toxicology 55:358-362, 2013.
10. Seifert, J. G., et al. Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. International Journal of Medical Sciences 8(3):192-197, 2011.
11. Stohs, S. J. and Preuss, H. G. Stereochemical and physiological differences between naturally occurring p-synephrine and synthetic p-synephrine. Journal of Functional Foods 4:2-5, 2012.
1. Yao, X., Parnot, C., Deupi, X., Ratnala, V. R., Swaminath, G., Farrens, D., & Kobilka, B. (2006). Coupling ligand structure to specific conformational switches in the β2-adrenoceptor. Nature chemical biology, 2(8), 417-422.
2. Shannon, H. E., Cone, E. J., & Yousefnejad, D. A. V. I. D. (1982). Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. Journal of Pharmacology and Experimental Therapeutics, 223(1), 190-196.
3. Aasen, A. J., Culvenor, C. C. J., Finnie, E. P., Kellock, A. W., & Smith, L. W. (1969). Alkaloids as a possible cause of ryegrass staggers in grazing livestock. Crop and Pasture Science, 20(1), 71-86.
4. Liapakis, G., Chan, W. C., Papadokostaki, M., & Javitch, J. A. (2004). Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the β2 adrenergic receptor. Molecular Pharmacology, 65(5), 1181-1190.
5. Osamu, S., Masakazu, O., & Yoshinao, K. (1980). Characterization of N-methylphenethylamine and N-methylphenylethanolamine as substrates for type A and type B monoamine oxidase. Biochemical pharmacology, 29(19), 2563-2566.
1. Kalman, D. S., Feldman, S., Samson, A., & Krieger, D. R. (2015). A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clinical pharmacology: advances and applications, 7, 103.
1. Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., Yamagami, T., Liu, Z., & Qi, B. (2004). Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino acids, 26(2), 203-207.
2. BOUCHAMA, A., YUSUF, A., AL-SEDAIRY, S. U. L. T. A. N., & EL-YAZIGI, A. D. N. A. N. (1993). Alteration of taurine homeostasis in acute heatstroke.Critical care medicine, 21(4), 551-554.
3. Gwacham, N., & Wagner, D. R. (2012). Acute effects of a caffeine-taurine energy drink on repeated sprint performance of American college football players. Int J Sport Nutr Exerc Metab, 22(2), 109-116.
4. Warskulat, U., Brookmann, S., Felsner, I., Brenden, H., Grether‐Beck, S., & Häussinger, D. (2008). Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts. Experimental dermatology, 17(12), 1031-1036.
1. Ahn, S. K., S. Hong, et al. (2011). "Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase." Brain Res 1373: 48-54.
2. Arndt, M. A., V. Battaglia, et al. (2009). "The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis." Am J Physiol Cell Physiol 296(6): C1411-1419.
3. Berkels, R., D. Taubert, et al. (2004). "Agmatine signaling: odds and threads." Cardiovasc Drug Rev 22(1): 7-16.
4. Gao, Y., B. Gumusel, et al. (1995). "Agmatine: a novel endogenous vasodilator substance." Life Sci 57(8): PL83-86.
5. Haenisch, B., I. von Kugelgen, et al. (2008). "Regulatory mechanisms underlying agmatine homeostasis in humans." Am J Physiol Gastrointest Liver Physiol 295(5): G1104-1110.
6. Halaris, A. and J. Plietz (2007). "Agmatine: metabolic pathway and spectrum of activity in brain." CNS Drugs 21(11): 885-900.
7. L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide.
8. Keynan, O., Mirovsky, Y., Dekel, S., Gilad, V. H., & Gilad, G. M. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc‐associated Radiculopathy. An Open‐label, Dose‐escalating Study Followed by a Randomized, Double‐blind, Placebo‐controlled Trial. Pain Medicine, 11(3), 356-368.
1. Elam, M. B., Hunninghake, D. B., Davis, K. B., Garg, R., Johnson, C., Egan, D., ... & ADMIT Investigators. (2000). Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Jama,284(10), 1263-1270.
2. Goldberg, A., Alagona, P., Capuzzi, D. M., Guyton, J., Morgan, J. M., Rodgers, J., ... & Samuel, P. (2000). Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. The American journal of cardiology, 85(9), 1100-1105.
3. Guyton, J. R. (2007). Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. Current opinion in lipidology, 18(4), 415-420.
1. Dellinger, R. W. (2014, August). Clinical evaluation of PURENERGY (TM), a novel co-crystal ingredient comprised of pterostilbene and caffeine, in healthy adults. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 248). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
2. Seeram, N. P. (2011). Emerging research supporting the positive effects of berries on human health and disease prevention. Journal of agricultural and food chemistry, 60
3. Rimando, A. M., Cuendet, M., Desmarchelier, C., Mehta, R. G., Pezzuto, J. M., & Duke, S. O. (2002). Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Journal of agricultural and food chemistry, 50(12), 3453-3457.
4. Sekhon, B. S. (2012). Nutraceutical cocrystals: an overview. RGUHS J. Pharm. Sci., 2, 16-25.
California’s Proposition 65 entitles California consumers to special warnings.
WARNING: Cancer and Reproductive Harm - www.P65warnings.ca.gov/
While not illegal, some of the ingredients found in this product could lead to a false positive drug test and may also be banned by WADA or other professional organizations such as the NCAA.
If you are a professional, college, or amateur athlete whose given sports conduct in and out of competition random drug screens is it highly recommended you check with the appropriate person before taking this product.