Thermogenic Skin Gel

Specifically formulated to help with targeted fat loss*
Reduces subcutaneous fat in conjunction with exercise*
Burns more calories while working out*
Increases thermogenesis/resting metabolic rate*
Supports tighter, firmer skin*
Provides energy*

Description

Fat – we all have those trouble spots. It could be the spare tire around your belly, or maybe some region that only seems to be affecting you personally (who put fat there anyway?!)

If only there was a product to directly address those areas that my eyes are glued to every time I look in the mirror – just roll it on and forget about it. Well, now there is!

MuscleSport is proud to present you with a fat-busting, rule-breaking skin gel formulation that is chock full of evidence-based ingredients ensured to attack the cellulite at its roots - AlphaShred!

Caffeine - Adrenaline-fueled breakdown and elimination of fatty acids
Carnitine - Drives fatty acids into the “furnace” of the cell: mitochondria
Iodine – Improves the action and function of your thyroid hormones to enhance fat metabolism
Escin – Proven topical venotonic: vasoprotective, vasoconstrictive, and anti-inflammatory; reduces causes of cellulite such as swelling, edema, and tissue damage
Glycyl-histidyl-lysine: Topical use can tighten loose skin and improve skin remodeling.

This amazing combination of ingredients attacks body fat in numerous ways. Metabolism enhancers result in increased breakdown, transport, and elimination of fats – the three components needed to be effective.

Venotonics ensure that the microcirculation (which tends to be limited in fat tissue) is working optimally.

This allows nutrients in to feed the skin, and pro-oxidants and xenobiotics out (that would normally cause damage). Skin remodelers round out the formulation so that you have an all-in-one fat-blaster/skin rejuvenator!

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

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Ingredient Description

Caffeine

Caffeine has been shown to exhibit a potent lipolytic effect in multiple studies. The mechanism involves an increased release of catecholamines.

Two studies showed an increase in adrenaline and noradrenaline [1, 2], and Norager et al. also observed increased free fatty acids in the blood [1]. The free fatty acids indicate lipolysis, which is the process of cleaving fatty acids from the glycerol backbone of the triglyceride, thereby making the fatty acids more available as a source of fuel (i.e. burning).
A second study demonstrated an increase in glycerol levels [3], which also indicates lipolysis (more cleaving fatty acids would increase the presence of glycerol backbones). Metabolic rate also increased, which means that overall fuel burning will go up.
Increases in both lipolysis and metabolic rate are a perfect match for eliminating unwanted fat since it means that more fuel (fat) needs to be burned and there is more fat available for burning.

Carnitine

The perfect complement to caffeine since the role of carnitine is to shuttle free fatty acids into the “furnace” of the cell – the mitochondria.

Carnitine is a substrate which gets bonded to fatty acids to allow them to be transported into the mitochondria – think of it as the horse that gets hooked onto the carriage.
Due to caffeine, fuel requirements are going up (need more horses and carriages) and fatty acids are more available (more carriages), it makes sense to provide additional carnitine (more horses).
Two studies have illustrated that carnitine can lower fat mass in individuals [4, 5], and one of the studies also observed a reduction in blood triglycerides, which support the mechanisms described above [4].

Yohimbine HCl

Another fantastic ingredient to pair with caffeine, yohimbine stimulates fat burning through both direct receptor activity and through an increase in adrenaline.

Yohimbine is a selective alpha2 adrenergic receptor antagonist, which has been shown to be related to increased lipolysis [6]. Use in a topical cream demonstrated a localized fat reduction in the thigh [7].

Iodine

Iodine compounds, such as Tea-hydroiodide, play an important role in promoting proper thyroid function. It is the chief component of thyroid hormones, which have a direct role in regulating metabolisms, such as lipolysis and fat oxidation (burning).

They can also sensitize the adipose tissue to actions of other lipolytic hormones.

In fact, many studies have shown that fat cells express receptors for Thyroid-stimulating hormone so that the hormone can directly act on these cells [8-10]. Therefore, maintaining healthy thyroid function and proper levels of thyroid hormones are essential to increased lipolysis and fat burning in the body.

Butcherbroom (Ruscus aculeatus)

The first of our powerful venotonic ingredients. Butcherbroom acts as a vasoconstrictor, such that capillaries in the local area will demonstrate improved blood flow by constricting, which reduces swelling of the area, edema, and then subsequent leakage from capillaries and tissue damage.

Edemas can develop in the first stages of cellulite, and vasoconstriction can defend against that development. Vanscheidt et al. showed a reduction in leg swelling and an improvement in people with chronic capillary issues [11].
In addition, butcherbroom can stimulate noradrenaline release, such that it can increase lipolysis due to the same mechanism as caffeine [12].

Ivy (Hedera helix)

An essential component for use in topical treatments for cellulite, due to its emollient and skin benefits and its vasoconstrictive properties [13].

Traditional medicine has utilized ivy for fat loss and cellulite removal. Its main action involves blood vessel protection and a reduction in capillary permeability, leading to lower leakage and edema.
Additionally, studies demonstrate the anti-inflammatory benefits of ivy administration [14, 15], which can help alleviate the body’s reaction to an exacerbation of the development of cellulite.

Escin

Escin is a mixture of saponins and an excellent venotonic. Similar to ivy, escin exhibits vasoprotective, vasoconstrictive, and anti-inflammatory benefits.

Multiple studies showed improved capillary action, skin perfusion, and general microcirculation benefit from topical administration of escin [16, 17].
Topical use of escin also showed a reduction in free radicals, such that escin evinces antioxidant protection along with improved skin perfusion and microcirculation [7].

Glycyl-histidyl-lysine

Functions to accelerate wound healing and skin repair in the body [18].

Topical use has resulted in the tightening of loose skin and improved skin elasticity, density, and firmness, and glycyl-histidyl-lysine is a known agent of skin remodeling [19].
Gruchlik et al. propose that glycyl-histidyl-lysine is such an effective topical anti-inflammatory that it can be used for skin inflammation instead of corticosteroids [20].

FAQs

Q: How do I use AlphaShred Topical Gel?

A: Before exercise, apply an ample amount of AlphaShred Topical Gel to the skin, coating all desired areas without rubbing it in completely.

Q: How will I get the best results from AlphaShred Topical Gel?

A: For best results do not use AlphaShred Topical Gel with any skin cream or lotion, as it creates a barrier that inhibits results. AlphaShred Topical Gel should be used under loose-fitting clothes to prevent friction and increase breathability. AlphaShred Topical Gel can also be used while swimming, and in dry or infrared saunas.

Q: Do I need to remove AlphaShred Topical Gel after working out?

A: After exercise, towel off AlphaShred Topical Gel before getting in the shower.

Q: What other MuscleSport products should I stack with AlphaShred Topical Gel?

A: For optimal results, stack AlphaCutz Topical Gel with the AlphaShred Advanced Cutting Kit.

References

1. Greenway, F. L., Bray, G. A., & Heber, D. (1995). Topical fat reduction. Obesity research, 3(S4), 561S-568S.

2. Caruso, M. K., Pekarovic, S., Raum, W. J., & Greenway, F. (2007). Topical fat reduction from the waist. Diabetes, Obesity and Metabolism, 9(3), 300-303.

3. Greenway, F. L., & Bray, G. A. (1987). Regional fat loss from the thigh in obese women after adrenergic modulation. Clin Ther, 9(6), 663-9.

4. Pedersen, S. B., Kristensen, K., Hermann, P. A., Katzenellenbogen, J. A., & Richelsen, B. (2004). Estrogen controls lipolysis by up-regulating α2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor α. Implications for the female fat distribution. The Journal of Clinical Endocrinology & Metabolism, 89(4), 1869-1878.

5. Norager, C.B., et al., Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Clin Endocrinol (Oxf), 2006. 65(2): p. 223-8.

6. Astrup, A., et al., Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr, 1990. 51(5): p. 759-67.

7. Keijzers, G.B., et al., Caffeine can decrease insulin sensitivity in humans. Diabetes Care, 2002. 25(2): p. 364-9.

8. Pistone, G., et al., Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile, and fatigue. Drugs Aging, 2003. 20(10): p. 761-7.

9. Malaguarnera, M., et al., L-Carnitine treatment reduces the severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr, 2007. 86(6): p. 1738-44.

10. Pedersen, S.B., et al., Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab, 2004. 89(4): p. 1869-78.

11. Ricci, A., et al., Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical data. Angiology, 2004. 55 Suppl 1: p. S11-4.

12. Davies, T., B. Smith, and R. Hall, Thyrotropin receptors in human fat. The New England journal of medicine, 1977. 296(13): p. 759-760.

13. Mullin, B.R., et al., Thyrotropin interactions with human fat cell membrane preparations and the finding of a soluble thyrotropin binding component. Biochemical and biophysical research communications, 1976. 69(1): p. 55-62.

14. Endo, T., et al., Cloning and functional expression of a thyrotropin receptor cDNA from rat fat cells. Journal of Biological Chemistry, 1995. 270(18): p. 10833-10837.

15. Vanscheidt, W., et al., Efficacy and safety of a Butcher's broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. Arzneimittelforschung, 2002. 52(4): p. 243-50.

16. Marcelon, G., et al., Effect of Ruscus aculeatus on isolated canine cutaneous veins. Gen Pharmacol, 1983. 14(1): p. 103-6.

17. Bruneton, J., Pharmacognosy, Phytochemistry, medicinal plants. 1995: Lavoisier publishing.

18. Schulte-Michels, J., et al., Ivy leaves dry extract EA 575(R) decreases LPS-induced IL-6 release from murine macrophages. Pharmazie, 2016. 71(3): p. 158-61.

19. Ebrahimi, H., et al., Effect of alpha-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats. Drug Dev Res, 2016. 77(2): p. 87-93.

20. Luzzi, R., et al., Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy. Panminerva Med, 2011. 53(3 Suppl 1): p. 51-5.

21. Ruffini, I., et al., Efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension. Angiology, 2004. 55 Suppl 1: p. S19-21.

22. Ehrlich, H. Stimulation of skin healing in immunosuppressed rats. in Proceedings of the Symposium on Collagen and Skin Repair. 1991.

23. Lubick, K., M. Radke, and M. Jutila, Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. Journal of leukocyte biology, 2007. 82(5): p. 1062-1069.

24. Gruchlik, A., et al., Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-α-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Polonia pharmaceutical, 2012. 69(6): p. 1303-1306.

WARNING

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm - www.P65warnings.ca.gov/

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